This means one must unlock Eve herself first, and then defeat both Satan and ? as Eve to unlock both the Razor Blade and Sacrificial Dagger respectively. To unlock the challenge, the save file must have everything used by this challenge unlocked on top of defeating Mom's Heart 11 times.Killing Delirium will count as completing the challenge.Also, to prevent Angel Rooms from appearing later on in the run, it is advised to take the first Devil Deal encountered.As such, opening the Devil Room as often as possible should be a priority. Since all of the starting items are from the Devil Room pool, Eve has a much higher chance to get some of the stronger items such as Mom's Knife or Brimstone.A Dark Bum can produce Soul Hearts, which can allow Eve to maintain a buffer of health while maintaining the Whore of Babylon's effect. However, this can put Eve in a very dangerous position with only one Red Heart. Making one Devil deal can permanently activate Whore of Babylon.The fear effect can drive enemies away, allowing Eve to chase and kill them with the dagger. Sacrificial Dagger and Dark Matter can be used together.Because the Razor Blade inflicts damage, using it will also activate the Dead Bird.Since she starts with 2 hearts, the Razor Blade can activate this effect immediately. Since the player is playing as Eve, Whore of Babylon will activate when having 1 Red Heart or less, rather than 1/2.

As a result, the majority of the challenge will be spent in a near-death state. When low on health, Eve can inflict more damage. This challenge focuses on a high risk, high reward style of play.

The binding of isaac rebirth challenges